PhD and Master Thesis Projects Available
Postdoc Position Available
We are looking for a postdoc to join the interdisciplinary biomembrane remodeling group at the Mathematical Institute, Faculty of Mathematics and Physics at Charles University, Prague. The aim of the project is the development of a toolkit for the description of biomembranes in contact with proteins and other complex adsorbates. We already have implemented a unique method to extract membrane material properties from molecular dynamics simulations. Our goal is to create and implement models to accurately describe large-scale membrane deformations in biorelevant systems. In particular, we are interested in understanding the morphology of mitochondria in the presence of membrane remodeling proteins. We aim to also include the effect of stressors, such as reactive oxygen species, ion imbalances, defective lipids or ATP depletion. The postdoc will have access to cryoelectron microscopy data as well as fluorescence microscopy images via our international scientific collaborations. Newly generated hypotheses can be tested locally at collaborating institutions. The starting date is as soon as possible, the initial project duration is 18 months. If you have further questions or would like to get in touch for a PhD project please to do not hesitate to contact the PI Christoph Allolio (allolio@karlin.mff.cuni.cz) Desired skills and experience
The successful applicant will have a solid background in physics, ideally thin shell elasticity or Helfrich theory. Knowledge of colloids, surfactants and interfacial electrostatics is an important plus. In addition, the ideal applicant will be well-versed in numerical methods/ scientific programming and is proficient in at least one programming language, preferably python or C++. Familiarity with the finite element method a plus. Expertise in molecular simulations, including enhanced sampling techniques as well as the GROMACS code is a plus. The project contains experimental work to be carried out in collaboration with different research institutes in Prague as well as collaboration partners in the USA and Israel. The applicant will have the freedom to emphasize either theory or simulation and may also conduct some experimental work. About the employer
Charles University is one of the oldest universities in Europe and the premier research university in the Czech Republic. The School of Mathematics including the Mathematical Modeling Group and Department of Numerical Mathematics is one of the leading units at the university. It has a world-class team in the field of numerical methods as well as theoretical continuum mechanics. Czech Republic has a well-functioning system of childcare, public health insurance and affordable public transport. The job will pay a competetive salary, includes pension contributions and social insurance. Additional benefits, such as a multisport card, are available. Due to possible travel restrictions, holders of a Schengen visa/EU citizens are especially encouraged to apply.
Areas of Research
- Computational Material Science
- Molecular Biophysics
- Life Sciences
Please contact the PI at allolio@karlin.mff.cuni.cz