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Notifications

We will meet at regular live zoom sessions on Mondays at 14:00. The last live zoom session is on May 31. It will cover sample size and power calculation for randomized studies.

The link for zoom sessions has been provided to the enrolled students by mail. It will remain valid for all zoom sessions during the semester.

Recordings will be published on an external separate site, the link will be provided below.

Schedule 

Schedule is not much relevant in times of distant teaching...

Lectures
Monday 14:00 - 15:30 K6  
Exercise Class
Wednesday 9:00 - 10:30 K4 (Instructor: Martin Otava)

Course Materials 

Progress of lectures

  1. Monday March 1. Introduction. Basic epidemiologic terms. Left truncated data.

    Course notes, Sec. 1.1-1.3, pp. 6-9.

    Supplementary reading: Esteve, Benhamou, Raymond (Chap. 1, pp. 1-13).

  2. Monday March 8. Empirical incidence estimates. Age-specific incidence, age-standardized incidence, cumulative incidence.

    Course notes, Sec. 1.4-1.5, pp. 9-14.

    Supplementary presentation on non-representative sampling.

    Supplementary reading: Esteve, Benhamou, Raymond (Chap. 2, pp. 49-62). BD1 (Sec. 2.1-2.3, pp. 42-53).

    Video recording:

    • lecture_02_210308.mp4: Empirical incidence estimates. Age-specific incidence, age-standardized incidence, cumulative incidence. (47 min.)
  3. Monday March 15. Exposure-disease associations. Introduction to epidemiological study design.

    Course notes, Sec. 1.6-2.1, pp. 14-19.

    Supplementary reading: BD1 (Sec. 2.4, 2.8, pp. 54-59, 69-73).

    Video recording:

    • lecture_03_210315.mp4: Exposure-disease associations. Introduction to epidemiological study design. (60 min.)
  4. Monday March 22. Odds ratio estimation and testing. Confounding in epidemiological studies.

    Course notes, Sec. 2.2-2.4, pp. 19-24.

    Supplementary reading: BD1, (Sec. 4.1-4.3, pp. 122-136, Sec. 3.4, pp. 93-108).

    Video recording:

    • lecture_04_210322.mp4: Odds ratio estimation and testing; confounding in epidemiological studies (47 min.)
  5. Monday March 29. Practical issues in epidemiological studies.

    Course notes, Sec. 2.5, pp. 25-28.

    Supplementary reading: BD1, (Sec. 1.2-1.5, pp. 19-32, Sec. 3.8, pp. 112-115).

    Video recording:

    • lecture_05_210329.mp4: Practical issues in epidemiological studies (30 min.)
  6. Monday April 12. Analysis of stratified case-control studies.

    Course notes, Sec. 3.1-3.3, pp. 29-36.

    Supplementary reading: BD1, (Sec. 4.4, pp. 136-146, Sec. 6.1-6.5, pp. 193-213).

    Video recording:

    • lecture_06_210412.mp4: Stratified case-control studies (65 min.)
  7. Monday April 19. Analysis of matched case-control studies.

    Course notes, Sec. 4.1-4.3, pp. 37-44.

    Supplementary reading: BD1, (Sec. 5.1-5.2, pp. 162-169, Sec. 7.1-7.4, pp. 248-268).

    Video recording:

    • lecture_07_210419.mp4: Matched case-control studies (71 min.)
  8. Monday April 26. Analysis of cohort studies: ungrouped and grouped data. Discrete Cox model.

    Course notes, Sec. 5.1-5.4, pp. 45-56.

    Supplementary reading: BD2, (Chap. 5, pp. 178-197, Chap. 3, pp. 82–91, Chap. 4, pp. 120–171).

    Video recording:

    • lecture_08_210426.mp4: Cohort studies (88 min.)
  9. Monday May 3. Diagnostic tests.

    Course notes, Sec. 6.1-6.4, pp. 57-63.

    Video recording:

    • lecture_09_210503.mp4: Diagnostic tests (36 min.)
  10. Monday May 10. Drug development process. Phases of clinical trials.

    Presentation I.

    Supplementary reading: FFD Chap. 1, pp. 1-14.

    Video recording:

    • lecture_10_210510.mp4: Drug development process. Phases of clinical trials (52 min.)
  11. Monday May 17. Phase III trials: protocol, objectives, endpoints, population, randomization, blinding.

    Presentation II.

    Clinical trial protocol contents (example).

    Supplementary reading: FFD Chap. 3, pp. 37-51, Chap. 4, pp. 55-65, Chap. 6, pp. 97-105, Chap. 7, pp. 119-131.

    Video recording:

    • lecture_11_210517.mp4: Phase III trials: protocol, objectives, endpoints, population, randomization, blinding. (47 min.)
  12. Monday May 24.  Phase III trials: study design, follow-up, ethical issues, analysis issues, adjustment for baseline.

    Presentation III.

    Supplementary reading: FFD Chap. 5, pp. 79-90, Chap 2, 19-32, Chap. 17, pp. 345-389.

    Video recording:

    • lecture_12_210524.mp4: Phase III trials: study design, follow-up, ethical issues, analysis issues, adjustment for baseline (61 min.)
  13. Monday May 31.  Sample size and power calculation in randomized trials.

    Course notes, Appendix A.1, pp. 68-72.

    Supplementary reading: FFD Chap. 8, pp. 133-161.

Homeworks 

Homework 1 (voluntary):

Read the article Challen R, Brooks-Pollock E, Read J M, Dyson L, Tsaneva-Atanasova K, Danon L et al. (2021) “Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study.” BMJ 372:n579.

Prepare a brief assessment of the study from the point of view of design, analysis and interpretation. Is it a sound study? Can its results be trusted? Are there any major flaws?

Deadline: May 17. We will discuss this paper at the May 17 session.

Textbooks 

Course Plan

We will learn statistical methods used in medicine, especially in epidemiology and clinical trials. Terminology specific to medical applications will be explained and some specialized methods will be covered. We will review study designs used in medical studies (cohort study, case-control study, randomized controlled trial) and explain how to analyze each of them. Ethical and administrative aspects of human experiments and their impact on handling statistical issues will be discussed.

Prerequisites

This course assumes advanced knowledge of statistical theory and practice, especially linear regression, logistic regression, loglinear models, survival analysis. Master students of "Probability, statistics and econometrics" must have completed the course on Linear Regression (NMSA407), Advanced Regression Models (NMST432), and Censored Data Analysis (NMST531) before enrolling in this course.